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NHS Sunderland Clinical Commissioning Group
South Tyneside and Sunderland NHS Foundation Trust
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 Formulary Chapter 5: Infections - Full Chapter
05.01  Expand sub section  Antibacterial drugs
05.01  Expand sub section  Table 1. Summary of antibacterial therapy
05.01  Expand sub section  Table 2. Summary of antibacterial prophylaxis
05.01.01  Expand sub section  Penicillins
05.01.01.01  Expand sub section  Benzylpenicillin and phenoxymethylpenicillin to top
Benzylpenicillin
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Formulary Injection: 600mg, 1.2g 
   
Phenoxymethylpenicillin (Penicllin V)
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Formulary Tablets: 250mg
Oral Solution (sugar-free available): 125/5ml, 250mg/5ml 
   
Benzathine penicillin
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Formulary
Red

unlicensed unlicensed Injection: 2.4MU vial

 
   
05.01.01.02  Expand sub section  Penicillinase-resistant penicillins
Flucloxacillin
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Formulary Capsules: 250mg, 500mg
Oral solution (sugar-free available): 125mg/5ml, 250mg/5ml 
   
Flucloxacillin
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Formulary
Red
Injection: 250mg, 500mg, 1g 
   
Temocillin
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Alternatives
Red
Vials: 1g*
*Hospital use only 
   
05.01.01.03  Expand sub section  Broad-spectrum penicillins
Amoxicillin
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Formulary Capsules: 250mg, 500mg
Oral suspension (sugar-free available): 125mg/5ml, 250mg/5ml
Oral sachets (sugar-free): 3g/sachet 
   
Amoxicillin
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Formulary
Red
Injection: 250mg, 500mg, 1g 
   
Co-Amoxiclav (amoxicillin with clavulanic acid)
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Formulary Tablets: 250/125, 500/125
Oral suspension (sugar-free available): 125/31, 250/62, 400/57

(Quantities are indicated in the form of x/y where x = mg amoxicillin and y = mg clavulanic acid) 
   
Co-Amoxiclav (amoxicillin with clavulanic acid)
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Formulary
Red
Injection: 500/100 (600mg), 1000/200 (1.2g)

(Quantities are indicated in the form of x/y where x = mg amoxicillin and y = mg clavulanic acid) 
   
05.01.01.04  Expand sub section  Antipseudomonal penicillins
Piperacillin and Tazobactam
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Formulary
Red
Injections: 2.25g (containing piperacillin 2g & tazobactam 250mg/2.25g vial) , 4.5g (containing piperacillin 4g & tazobactam 500mg/4.5g vial) 
   
05.01.01.05  Expand sub section  Mecillinams
Pivmecillinam
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Formulary Tablets: 200mg 
   
05.01.02  Expand sub section  Cephalosporins, carbapenems and other beta-lactums to top
Ceftolozane & tazobactam (Zerbaxa®)
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Formulary
Red

Solution for infusion: 1g/0.5g

 
   
05.01.02  Expand sub section  Cephalosporins
05.01.02  Expand sub section  Other beta-lactam antibiotics
05.01.02.01  Expand sub section  Cephalosporins
Cefalexin
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Formulary Capsules: 250mg, 500mg
Oral suspension: 125mg/5ml, 250mg/5ml 
   
Cefixime
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Formulary
Green +
Tablets: 200mg
Oral solution: 100mg/5ml 
   
Cefotaxime
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Formulary Injection: 500mg, 1g, 2g 
   
Ceftazidime
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Formulary
Red
Injection: 500mg, 1g, 2g, 3g 
   
Ceftriaxone
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Formulary Injection: 250mg, 1g, 2g 
   
Cefuroxime
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Formulary
Red
Injection: 250mg, 750mg, 1.5g 
   
05.01.02.02  Expand sub section  Carbapenems
Ertapenem
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Formulary
Red
Injection: 1g 
   
Meropenem
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Formulary
Red
Injection: 500mg, 1g 
   
05.01.02.03  Expand sub section  Other beta-lactums antibiotics to top
Aztreonam
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Formulary
Red
Injection: 1g, 2g
Powder for inhalation: 75mg

Approved in line with NHS England specialised commissioning criteria for the treatment of chronic pulmonary Pseudomonas aeruginosa infection in patients with cystic fibrosis.
Only to be prescribed by secondary care from April 2016 in line with NHS England Clinical Commissioning Policy 
Link  NHS England Clinical Commissioning Policy
   
05.01.03  Expand sub section  Tetracyclines
Doxycycline
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Formulary Capsules: 50mg, 100mg
Dispersible tablets: 100mg 
   
Lymecycline
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Formulary Capsules: 408mg (= tetracycline 300mg) 
   
Minocycline
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Formulary Tablets: 50mg, 100mg 
   
Oxytetracycline
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Formulary Tablets: 250mg 
   
Doxycycline
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Unlicensed Drug Unlicensed
Red
Injection: 100mg 
   
05.01.03  Expand sub section  Tigecycline
Tigecycline
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Formulary
Red
Injection: 50mg 
   
05.01.04  Expand sub section  Aminoglycosides
Amikacin
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Formulary
Red

Injection: 100mg/2ml, 500mg/2ml

 
   
Gentamicin
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Formulary
Red
Injection: 20mg/2ml, 40mg/1ml, 80mg/2ml 
   
Tobramycin inhaler (TOBI Podhaler®)
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Formulary
Red
High Cost Medicine
TOBI Podhaler: 28mg

Approved in line with NHS England specialised commissioning criteria for the treatment of chronic pulmonary Pseudomonas aeruginosa infection in patients with cystic fibrosis.
Only to be prescribed by secondary care from April 2016 in line with NHS England Clinical Commissioning Policy.
 
Link  NHS England Clinical Commissioning Policy
Link  NICE TA276: Cystic fibrosis (pseudomonas lung infection) - colistimethate sodium and tobramycin
   
05.01.05  Expand sub section  Macrolides
Erythromycin
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Formulary Tablets: 250mg, 500mg
Oral suspension (sugar-free available): 125mg/5ml, 250mg/5ml, 500mg/5ml 
   
Azithromycin
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Formulary Tablets: 250mg, 500mg
Capsules: 250mg
Oral suspension: 200mg/5ml

The tablets have a lower acquisition cost than the capsules

N.B. Green+ for use in COPD 
   
Clarithromycin
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Formulary Tablets: 250mg, 500mg
Oral suspension: 125/5ml, 250mg/5ml 
   
Erythromycin
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Formulary
Red

Injection for infusion: 1g vial*


*For use as a prokinetic

 
   
Clarithromycin
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Formulary
Red
Injection (for IV infusion): 500mg 
   
05.01.06  Expand sub section  Clindamycin to top
Clindamycin
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Formulary Capsules: 75mg, 150mg
Suspension: 75mg/5ml 
   
Clindamycin
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Formulary
Red
Injection: 300mg/2ml, 600mg/4ml 
   
05.01.07  Expand sub section  Some other antibacterials
Fosfomycin (Monuril)
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Formulary Sachets: 3g 
   
05.01.07  Expand sub section  Chloramphenicol
Chloramphenicol
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Formulary Capsules: 250mg 
   
Chloramphenicol
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Formulary
Red
Injection (for IV infusion): 1g 
   
05.01.07  Expand sub section  Fusidic acid
Sodium fusidate
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Formulary
Green +

Tablets: 250 mg
Oral suspension: 250 mg/5 mL (as fusidic acid)

 
   
Sodium fusidate
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Formulary
Red

Vial: powder and solvent for solution for infusion, 500 mg

 

 
   
05.01.07  Expand sub section  Vancomycin and teicoplanin
Teicoplanin
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Formulary
Red
Injection (for IV infusion): 200mg, 400mg 
   
Vancomycin
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Formulary
Green +
Capsules: 125mg 
   
Vancomycin
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Formulary
Red
Injection (for IV infusion): 500mg, 1g 
   
05.01.07  Expand sub section  Daptomycin to top
Daptomycin
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Formulary
Red
Injection (for IV infusion): 350mg, 500mg 
   
05.01.07  Expand sub section  Linezolid
Linezolid
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Formulary
Green +
Tablets: 600mg
Oral solution: 100mg/5ml 
   
Linezolid
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Formulary
Red
IV infusion: 600mg/300ml 
   
05.01.07  Expand sub section  Quinupristin and dalfopristin
05.01.07  Expand sub section  Polymyxins
Colistimethate inhaler (Colobreathe®)
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Formulary
Red
High Cost Medicine
Dry powder for inhalation: 1.66 million units per capsule (Colobreathe®)

Approved in line with NHS England specialised commissioning criteria for the treatment of chronic pulmonary Pseudomonas aeruginosa infection in patients with cystic fibrosis.
Only to be prescribed by secondary care from April 2016 in line with NHS England Clinical Commissioning Policy.
 
Link  NHS England Clinical Commissioning Policy
Link  NICE TA276: Cystic fibrosis (pseudomonas lung infection) - colistimethate sodium and tobramycin
   
Colistimethate sodium
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Formulary
Red
High Cost Medicine
Injection: 1,000,000 units, 2,000,000 units
Powder for nebulised solution: 1,000,000 units 
   
05.01.07  Expand sub section  Rifaximin
Rifaximin
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Formulary
Green +
Tablets: 550mg 
Link  NICE TA337: Rifaximin for preventing episodes of overt hepatic encephalopathy
   
05.01.07  Expand sub section  Fidaxomicin to top
Fidaxomicin
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Formulary
Green +

Tablets: 200mg

MUST ONLY BE PRESCRIBED ON THE ADVICE OF A MICROBIOLOGIST

See also link above to Risk assessment tool for C Difficile.

 
   
05.01.08  Expand sub section  Sulphonamides and trimethoprim
Co-trimoxazole
(Sulphamethoxazole 5 parts and trimethoprim 1 part)
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Formulary Tablets: 480mg, 960mg
Suspension: 480mg/5ml
 
   
Co-trimoxazole
(Sulphamethoxazole 5 parts and trimethoprim 1 part)
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Formulary
Red
480mg in 5ml ampoules for IV infusion 
   
Trimethoprim
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Formulary Tablets: 100mg, 200mg
Oral suspension: 50mg/5ml 
   
05.01.09  Expand sub section  Antituberculosis drugs
Ethambutol
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Formulary
Green +

Tablets: 100mg, 400mg
Suspension: 400mg/5ml. This is the nationally recommended standard strength.

Standardising strengths of high risk, unlicensed oral liquids formulations for anti-TB medicines.

 
   
Isoniazid
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Formulary
Green +

Tablets: 50mg, 100mg

Liquid 50mg in 5ml . This is the nationally recommended standard strength.

Standardising strengths of high risk, unlicensed oral liquids formulations for anti-TB medicines.

 

 
   
Isoniazid
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Formulary
Red
Injection: 50mg/2ml 
   
Rifampicin
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Formulary Capsules: 150mg, 300mg
Oral syrup: 100mg/5ml

N.B. these formulations are GREEN+ when used in the treatment of tuberculosis 
   
Rifampicin
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Formulary
Red
IV infusion: 600mg vials for IV infusion 
   
Rifampicin and Isoniazid
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Formulary
Green +

Tablets: Rifinah® 150 tablets - rifampicin 150mg & isoniazid 100mg, Rifinah® 300 tablets - rifampicin 300mg & isoniazid 150mg

 
   
Rifampicin and Isoniazid and Pyrazinamide (Rifater®)
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Formulary
Green +
Tablets: Rifater® tablets- rifampicin 120mg, isoniazid 50mg & pyrazinamide 300mg 
   
Pyrazinamide
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Unlicensed Drug Unlicensed
Green +

Tablets: 500mg

Liquid: 500mg/5ml. This is the nationally recommended strength:

Standardising strengths of high risk, unlicensed oral liquids formulations for anti-TB medicines.

 
   
Streptomycin
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Unlicensed Drug Unlicensed
Red
Injection: 1g 
   
05.01.10  Expand sub section  Antileprotic drugs
Dapsone
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Formulary
Green +

Tablets: 50mg, 100mg

Used for the treatment of leprosy and some skin conditions (e.g. dermatitis herpetiformis, pemphigoid on the advice of dermatologists)

 
   
05.01.11  Expand sub section  Metronidazole and tinidazole
Metronidazole
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Formulary Tablets: 200mg, 400mg, 500mg
Suspension: 200/5ml
Suppositories: 500mg, 1g

 
   
Metronidazole
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Formulary
Red

IV infusion: 100mg/20ml, 500mg/100ml

 
   
Tinidazole
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Alternatives
Green +
Tablets: 500mg*
*After consultation with microbiology only 
   
05.01.12  Expand sub section  Quinolones to top
Ciprofloxacin
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Formulary
Red
IV infusion: 2mg/ml 
   
Ciprofloxacin
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Formulary Tablets: 100mg, 250mg, 500mg, 750mg
Oral suspension: 250mg/5ml 
   
Moxifloxacin
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Formulary Tablets: 400mg 
   
Ofloxacin
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Formulary Tablets: 200mg, 400mg 
   
Ofloxacin
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Formulary
Red
IV infusion: 200mg/100ml 
   
Levofloxacin
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Formulary
Red

Tablets: 500mg (12 week prophylactic course in patients with myeloma)

 
   
Moxifloxacin
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Formulary
Red

Injection for infusion: 400 mg/250mL

 
   
05.01.13  Expand sub section  Urinary-tract infections
Methenamine Hippurate (Hiprex®)
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Formulary
Green +

Tablets 1g

BNF states this drug is "Less suitable for prescribing". 

May be initiated as a Green plus drug by urology in some patients and can be continued in general practice in these circumstances.

Please clarify with the specialist the duration of treatment.

 
Link  BNF advice for the prescribing of methenamine hippurate
   
Nitrofurantoin
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Formulary Tablets: 50mg, 100mg
MR capsules: 100mg
Oral suspension (sugar-free available): 25mg/5ml*

*Note: Liquid presentations of nitrofurantoin are very expensive compared to tablets and capsules. Current costs are £446.95 for 300ml (May 2017 drug tariff). Please consider whether capsules can be used. Macrodantin capsules can either be swallowed whole, or the capsules can be opened. DO NOT crush the tablets 
   
05.02  Expand sub section  Antifungal drugs
Amphotericin
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Formulary
Red
High Cost Medicine
Injection (for IV infusion): 50mg
Liposomal injection (for IV infusion) (AmBisome®): 50mg 
   
Fluconazole
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Formulary Capsules: 50mg, 150mg, 200mg
Oral solution: 50mg/5ml, 200mg/5ml 
   
Fluconazole
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Formulary
Red
IV infusion: 50mg/25ml, 200mg/100ml 
   
Itraconazole
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Formulary Capsules: 100mg
Oral solution: 50mg/5ml 
   
Posaconazole (oral)
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Formulary
High Cost Medicine
Oral solution: 200mg/5ml 
   
Terbinafine
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Formulary Tablets: 250mg 
   
Voriconazole
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Formulary
Red
High Cost Medicine
Tablets: 50mg, 200mg
Injection (for IV infusion): 200mg

To be used for:
-Prophylaxis of fungal infection in haematological malignancy
-Treatment of invasive aspergillosis
-Treatment of candida infections resistant to narrower-spectrum azoles
-Treatment of scedosporium and fusarium infections
 
   
05.02  Expand sub section  Treatment of fungal infections
05.02  Expand sub section  Drugs used in fungal infections
Nystatin
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Formulary Oral suspension: 100,000 units/ml 
   
05.02.01  Expand sub section  Triazole antifungals to top
05.02.02  Expand sub section  Imidazole antifungals
05.02.03  Expand sub section  Polyene antifungals
05.02.04  Expand sub section  Echinocandin antifungals
Caspofungin
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Formulary
Red
High Cost Medicine
Injection: 50mg, 70mg 
   
05.02.05  Expand sub section  Other antifungals
05.03  Expand sub section  Antiviral drugs to top
Letermovir
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Formulary
Red
NHS England

Letermovir is recommended, within its marketing authorisation, as an option for preventing cytomegalovirus (CMV) reactivation and disease after an allogeneic haematopoietic stem cell transplant (HSCT) in adults who are seropositive for CMV. It is recommended only if the company provides it according to the commercial arrangement.

 
Link  NICE TA 591: Letermovir for preventing cytomegalovirus disease after a stem cell transplant
   
Remdesivir (Veklury®)
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Formulary
Red

Remdesivir 100mg/20mL concentrate for solution for infusion

Remdesivir 100mg powder for concentrate for solution for infusion

 
   
05.03.01  Expand sub section  HIV infection
05.03.01  Expand sub section  Antiviral medications
Abacavir (Ziagen®)
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Formulary
Red
High Cost Medicine

Tablets: 300mg
Oral solution: 20mg/ml

 
   
Abacavir and Lamivudine (Kivexa®)
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Formulary
Red
High Cost Medicine

Tablets: 600mg/300mg

 
   
Abacavir,Lamivudine and Zidovudine (Trizivir®)
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Formulary
Red
High Cost Medicine

Tablets: 150/300/300mg

 
   
Atazanavir (Reyataz®)
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Formulary
Red
High Cost Medicine

Capsules: 150mg, 200mg, 300mg

 
   
Atazanavir sulfate and cobicistat (Evotaz®)
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Formulary
Red

Tablets: 300mg/150mg

 
   
Cobicistat (Tybost®)
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Formulary
Red
High Cost Medicine

Tablets: 150mg

 
   
Darunavir (Prezista®)
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Formulary
Red
High Cost Medicine

Tablets: 75mg, 150mg, 400mg, 600mg, 800mg
Oral suspension: 100mg/ml

 
   
Darunavir and cobicistat (Rezolsta®)
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Formulary
Red
High Cost Medicine

Tablets: 800mg/150mg

 
   
Didanosine (Videx®)
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Formulary
Red
High Cost Medicine

Chewable tablets: 25mg
E/C capsules: 125mg, 200mg, 250mg, 400mg

 
   
Dolutegravir (Tivicay®)
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Formulary
Red
High Cost Medicine

Tablets: 10mg, 25mg, 50mg

 
   
Dolutegravir, abacavir and lamivudine (Triumeq®)
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Formulary
Red
High Cost Medicine

Tablets: 50mg/600mg/300mg

 
   
Efavirenz (Sustiva®)
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Formulary
Red
High Cost Medicine

Tablets: 600mg
Capsules: 50mg, 100mg 200mg

 
   
Elvitegravir (Vitekta)
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Formulary
Red

Tablets: 85mg, 150mg

 
   
Emtricitabine (Emtriva®)
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Formulary
Red
High Cost Medicine

Capsules: 200mg
Oral solution: 10mg/ml

 
   
Emtricitabine and tenofovir (Descovy®)
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Formulary
Red

Tablets: 200mg/10mg
Tablets: 200mg/25mg 

 
   
Emtricitabine rilpivirine and tenofovir (Eviplera®)
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Formulary
Red
High Cost Medicine

Tablets: 200mg/25mg/245mg

 
   
Emtricitabine, rilpivirine and tenofovir (Odefsey®)
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Formulary
Red

Tablets: 200mg/25mg/25mg

 
   
Enfuvirtide (Fuzeon®)
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Formulary
Red
High Cost Medicine

Powder and solvent for solution for injection vials: 108mg

 
   
Etravirine (Intelence®)
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Formulary
Red
High Cost Medicine

Tablets: 25mg, 100mg, 200mg

 
   
Fosamprenavir (Telzir®)
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Formulary
Red
High Cost Medicine

Tablets: 700mg
Oral suspension: 50mg/ml

 
   
Indinavir (Crixivan®)
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Formulary
Red
High Cost Medicine

Capsules: 200mg

 
   
Lamivudine (Epivir®, Zeffix®)
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Formulary
Red
High Cost Medicine

Tablets: 100mg, 150mg, 300mg (brands include Epivir®, Zeffix®)
Oral solution: 50mg/5ml (Epivir®)

 
   
Lopinavir and ritonavir (Kaletra®)
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Formulary
Red
High Cost Medicine

Tablets: 100mg/25mg, 200mg/50mg
Oral solution: 400mg/100mg in 5ml

 
   
Maraviroc (Celsentri®)
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Formulary
Red
High Cost Medicine

Tablets: 150mg, 300mg

 
   
Nevirapine (Viramune®)
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Formulary
Red
High Cost Medicine

Oral suspension: 10mg/1ml
MR tablets: 100mg, 400mg
Tablets: 200mg

 
   
Raltegravir (Isentress ®)
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Formulary
Red
High Cost Medicine

Tablets: 400mg

 
   
Rilpivirine hydrochloride (Edurant®)
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Formulary
Red
High Cost Medicine

Tablets: 25mg

 
   
Ritonavir (Norvir®)
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Formulary
Red
High Cost Medicine

Tablets: 100mg

 
   
Saquinavir (Invirase®)
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Formulary
Red
High Cost Medicine

Tablets: 500mg

 
   
Stavudine (Zerit®)
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Formulary
Red
High Cost Medicine

Capsules: 20mg, 30mg, 40mg
Oral solution: 1mg/ml

 
   
Tenofovir and emtricitabine (Truvada®)
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Formulary
Red
High Cost Medicine

Tablets containing: 200mg of emtricitabine and 245mg of tenofovir disoproxil (equivalent to 300mg of tenofovir disoproxil fumarate or 136mg of tenofovir)

 
   
Tenofovir disoproxil (Viread®)
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Formulary
Red

Tablets: 123mg, 163mg, 204mg, 245mg (as tenofovir disoproxil fumarate)

 
   
Tenofovir Disproxil
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Formulary
Red
High Cost Medicine
Tablets: 245mg
Granules (sugar-free): 33mg/1g (7.5g contains approximately 245mg tenofovir disoproxil) 
Link  NICE CG165: Hepatitis B (chronic) - incorporates TA173
Link  NICE TA173: Hepatitis B (chronic) - tenofovir disoproxil
   
Tenofovir, cobicistat, elvitegravir and emtricitabine (Stribild®)
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Formulary
Red
High Cost Medicine

Tablets: 150mg/150mg/200mg/245mg

 
   
Tenofovir, efavirenz and emtricitabine (Atripla®)
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Formulary
Red
High Cost Medicine

Tablets: 600mg/200mg/245mg

 
   
Tipranavir (Aptivus®)
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Formulary
Red
High Cost Medicine

Oral solution: 100mg/ml
Capsules: 250mg

 
   
Zidovudine (Retrovir®)
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Formulary
Red
High Cost Medicine

Capsules: 100mg, 250mg
Oral solution: 50mg/5ml
Solution for infusion: 200mg/20ml

 
   
Zidovudine and lamivudine (Combivir®)
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Formulary
Red

Tablets: 150mg/300mg

 
   
05.03.01  Expand sub section  Protease inhibitors
05.03.01  Expand sub section  Non-nucleoside reverse transcriptase inhibitors
05.03.01  Expand sub section  Other antiretrovirals to top
05.03.01  Expand sub section  Pharmacokinetic enhancers of antiretrovirals
05.03.02  Expand sub section  Herpesvirus infections
05.03.02.01  Expand sub section  Herpes simplex and varicella-zoster infection
Aciclovir
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Formulary Tablets: 200mg, 400mg, 800mg
Dispersible tablets: 200mg, 400mg, 800mg
Oral suspension (sugar-free available): 200mg/5ml, 400mg/5ml 
   
Aciclovir
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Formulary
Red
Injection (for IV infusion): 250mg, 500mg 
   
Valaciclovir (Valtrex®)
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Formulary Tablets: 500mg 
   
05.03.02.02  Expand sub section  Cytomegalovirus infrection
Ganciclovir
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Formulary
Red
High Cost Medicine
IV infusion: 500mg 
   
Valganciclovir
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Alternatives
Green +
High Cost Medicine
Tablets: 450mg 
   
05.03.03  Expand sub section  Viral hepatitis to top
05.03.03.01  Expand sub section  Chronic hepatitis B
Entecavir
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Formulary
Red
High Cost Medicine
Tablets: 500 micrograms (white), 1mg (pink)
Oral solution: 250 micrograms/5ml 
Link  NICE CG165: Hepatitis B (incorporates TA153)
Link  NICE TA153: Hepatitis B (chronic) - etecavir
   
05.03.03.02  Expand sub section  Chronic hepatitis C
Ledipasvir and Sofosbuvir (Harvoni®)
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Formulary
Red
High Cost Medicine
Tablets: 400mg/90mg 
Link  NICE TA363: Ledipasvir–sofosbuvir for treating chronic hepatitis C
   
Ombitasvir/ paritaprevir/ ritonavir (Viekirax®)
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Formulary
Red
High Cost Medicine
Tablets containing ombitasvir 12.5mg, paritaprevir 75mg and ritonavir 50mg 
Link  NICE TA365: Ombitasvir–paritaprevir–ritonavir with or without dasabuvir for treating chronic hepatitis C
   
Sofosbuvir
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Formulary
Red
High Cost Medicine
Tablets: 400mg 
Link  NICE TA330: Sofosbuvir for treating chronic hepatitis C
   
Sofosbuvir/velpatasvir/voxilaprevir (Vosevi)
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Formulary
Red

Tablets: 400mg/100mg/100mg

 
Link  NICE TA 507: Sofosbuvir–velpatasvir–voxilaprevir for treating chronic hepatitis C
   
Glencaprevir-pibrentasvir (Maviret)
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Formulary
Red

Tablets: 300mg/120mg

 
Link  NICE TA 499: Glecaprevir–pibrentasvir for treating chronic hepatitis C
   
05.03.04  Expand sub section  Influenza
Oseltamivir (Tamiflu®)
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First Choice Capsules: 30mg, 45mg, 75mg
Oral suspension (sugar-free): 30mg/5ml 
Zanamivir inhalation
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Alternatives Dry powder for inhalation: 5mg/blister (via Diskhaler®
   
05.03.05  Expand sub section  Respiratory syncytial virus
Ribavirin
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Formulary
Red
High Cost Medicine
Capsules: 200mg
Tablets: 200mg
Oral solution: 200mg/5ml 
Link  NICE TA75: Hepatitis C - pegylated interferons, ribavirin and alfa interferon
Link  NICE TA106: Hepatitis C - peginterferon alfa and ribavirin
Link  NICE TA200: Hepatitis C - peginterferon alfa and ribavirin
Link  NICE TA300: Hepatitis C (children and young people) - peginterferon alfa and ribavirin
   
05.04  Expand sub section  Antiprotozoal drugs to top
05.04.01  Expand sub section  Antimalarials
05.04.01  Expand sub section  Treatment of malaria
Artesunate (Malacef 60)
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Formulary
Red

Injection: 60mg

 
   
05.04.01  Expand sub section  Falciparum malaria (treatment)
05.04.01  Expand sub section  Benign malarias (treatment)
05.04.01  Expand sub section  Prophylaxis against malaria to top
05.04.01  Expand sub section  Specific recommendations
05.04.01  Expand sub section  Artemether with lumefabtrine
05.04.01  Expand sub section  Chloroquine
05.04.01  Expand sub section  Mefloquine
05.04.01  Expand sub section  Primaquine to top
05.04.01  Expand sub section  Proguanil
05.04.01  Expand sub section  Pyrimethamine
05.04.01  Expand sub section  Quinine
05.04.01  Expand sub section  Tetracyclines
05.04.02  Expand sub section  Amoebicides to top
05.04.03  Expand sub section  Trichomonacides
05.04.04  Expand sub section  Antigiardial drugs
05.04.05  Expand sub section  Leishmaniacides
05.04.06  Expand sub section  Trypanocides
05.04.07  Expand sub section  Drugs for toxoplasmosis to top
05.04.08  Expand sub section  Drugs for pneumocystis pneumonia
05.04.08  Expand sub section  Treatment
05.04.08  Expand sub section  Prophylaxis
05.05  Expand sub section  Anthelmintics
05.05.01  Expand sub section  Drugs for threadworms to top
Mebendazole
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Formulary Tablets (chewable): 100mg
Oral suspension: 100mg/5ml 
   
05.05.02  Expand sub section  Ascaricides
05.05.03  Expand sub section  Drugs for tapeworm infections
05.05.03  Expand sub section  Taenicides
05.05.03  Expand sub section  Hydatid disease
05.05.04  Expand sub section  Drugs for hookworms to top
05.05.05  Expand sub section  Schistosomicides
05.05.06  Expand sub section  Filaricides
05.05.07  Expand sub section  Drugs for cutaneous larva migrans
05.05.08  Expand sub section  Drugs for strongyloidiasis
 ....
 Non Formulary Items
Adefovir Dipivoxil  (Hepsera®)

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Non Formulary
High Cost Medicine
Link  NICE CG165: Hepatitis B (chronic) - incorporates TA96
Link  NICE TA96: Hepatitis B (chronic) - adefovir dipivoxil and pegylated interferon alpha-2a
 
Albendazole

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Non Formulary
 
Amantadine Hydrochloride  (Symmetrel®)

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Non Formulary
 
Aminosalicylic acid  (Granupas®)

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Non Formulary
 
Ampicillin  (Penbritin®)

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Non Formulary
 
Amprenavir  (Agenerase®)

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Non Formulary
 
Anidulafungin

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Non Formulary
High Cost Medicine
 
Artemether with lumefantrine  (Riamet®)

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Non Formulary
 
Atovaquone

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Non Formulary
 
Bedaquiline  (Sirturo® )

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Non Formulary
High Cost Medicine
 
Capreomycin  (Capastat®)

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Non Formulary
 
Cefaclor

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Non Formulary
 
Cefadroxil

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Non Formulary
 
Cefpodoxime

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Non Formulary
 
Cefradine

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Non Formulary
 
Ceftaroline  (Zinforo®)

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Non Formulary
 
Ceftobiprole  (Zevtera®)

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Non Formulary
 
Chloroquine

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Non Formulary
 
Cidofovir infusion  (Vistide®)

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Non Formulary
High Cost Medicine
 
Clofazimine

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Non Formulary
 
Co-Fluampicil

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Non Formulary
 
Collatamp EG Sponge

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Non Formulary
 
Cycloserine

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Non Formulary
 
Dalbavancin

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Non Formulary
 
Dasabuvir  (Exviera®)

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Non Formulary
High Cost Medicine
 
Delamanid  (Deltyba®)

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Non Formulary
High Cost Medicine
 
Demeclocycline  (Ledermycin®)

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Non Formulary
 
Diloxanide

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Non Formulary
 
Famciclovir  (Famvir®)

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Non Formulary
 
Flucytosine  (Ancotil®)

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Non Formulary
 
Foscarnet Sodium  (Foscavir®)

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Non Formulary
High Cost Medicine
 
Griseofulvin

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Non Formulary
 
Griseofulvin  (Fulsovin®)

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Non Formulary
 
Imipenem with Cilastatin  (Primaxin®)

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Non Formulary
 
Inosine Pranobex  (Imunovir®)

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Non Formulary
 
Isavuconazole  (Cresemba®)

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Non Formulary
 
Ketoconazole  (Nizoral®)

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Non Formulary
 
Lamivudine & Raltegravir  (Dutrebis®)

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Non Formulary
 
Mefloquine  (Lariam®)

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Non Formulary
 
Mepacrine Hydrochloride

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Non Formulary
 
Micafungin  (Mycamine®)

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Non Formulary
High Cost Medicine
 
Miconazole  (Daktarin®)

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Non Formulary
 
Nalidixic Acid  (Uriben®)

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Non Formulary
 
Nelfinavir  (Viracept®)

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Non Formulary
High Cost Medicine
 
Neomycin Sulphate

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Non Formulary
 
Netilmicin  (Netillin®)

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Non Formulary
 
Niclosamide

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Non Formulary
 
Norfloxacin

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Non Formulary
 
Oritavancin  (Orbactiv®)

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Non Formulary
 
Palivizumab  (Synagis®)

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Non Formulary
High Cost Medicine
 
Pentamidine Isetionate  (Pantacarinat®)

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Non Formulary
 
Piperazine

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Non Formulary
 
Posaconazole (IV)  (Noxafil®)

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Non Formulary
High Cost Medicine
 
PRAZIQUANTEL Tablets 500 mg

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Non Formulary
 
Primaquine

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Non Formulary
 
Procaine Penicillin G Injection

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Non Formulary
 
Proguanil Hydrochloride

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Non Formulary
 
Proguanil Hydrochloride with Atovaquone

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Non Formulary
 
Prothionamide

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Non Formulary
 
Pyrimethamine  (Darprim®)

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Non Formulary
 
Pyrimethamine and Dapsone

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Non Formulary
 
Pyrimethamine with Sulfadoxine  (Fansidar®)

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Non Formulary
 
Quinine

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Non Formulary
 
Quinine Bisulphate

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Non Formulary
 
Quinupristin and dalfopristin  (Synercid®)

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Non Formulary
 
Rifabutin  (Mycobutin®)

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Non Formulary
 
Rifampicin, isoniazid, pyrazinamide and ethambutol  (Voractiv®)

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Non Formulary
 
Rilpiverine, emtrictabine and tenofovir alafenamide

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Non Formulary
 
Sinecatechins  (Veregen)

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Non Formulary
 
Sodium Stibogluconate  (Pentostam®)

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Non Formulary
 
Sulfadiazine

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Non Formulary
 
Sulfadiazine

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Non Formulary
 
Tedizolid  (Sivextro®)

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Non Formulary
 
Telavancin

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Non Formulary
 
Telithromycin  (Ketek®)

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Non Formulary
 
Tenofovir alafenamide, Elvitegravir, Cobicistat & Emtricitabine  (Genvoya®)

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Non Formulary
 
Tetracycline

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Non Formulary
 
Thalidomide

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Non Formulary
 
TIABENDAZOLE 500mg tabs

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Non Formulary
 
Ticarcillin with clavulanic acid  (Timentin®)

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Non Formulary
 
Zanamivir Injection

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Non Formulary
 
  
Key
note Notes
Section Title Section Title (top level)
Section Title Section Title (sub level)
First Choice Item First Choice item
Non Formulary Item Non Formulary section
Restricted Drug
Restricted Drug
Unlicensed Drug
Unlicensed
Track Changes
Display tracking information
click to search medicines.org.uk
Link to adult BNF
click to search medicines.org.uk
Link to SPCs
Cytotoxic Drug
Cytotoxic Drug
CD
Controlled Drug
High Cost Medicine
High Cost Medicine
Cancer Drugs Fund
Cancer Drugs Fund
NHSE
NHS England
Homecare
Homecare
CCG
CCG

Traffic Light Status Information

Status Description

Red

Drugs for hospital use or use by a specialist within specialist centre only. Initiation and monitoring of treatment should remain under the total responsibility of the appropriate hospital clinician or specialist. These drugs should only be prescribed under the direct supervision of that clinician or specialist and are not suitable for shared care arrangements. The drug should be supplied via the hospital or specialist centre for the duration of treatment.   

Amber

These are specialist drugs which must be initiated by secondary care specialist prescribers, but with the potential to transfer prescribing to primary care within written and agreed shared care protocols and according to the agreed process for transfer of care. For these drugs, in order to ensure patient safety, some aspects of care must remain with the specialist due to their complexity e.g. monitoring of disease or drug response. Other more routine aspects can be transferred to the GP e.g. monitoring of adverse effects and supply of the medicine. The specific responsibilities of the specialist and GP are defined in the shared care agreement for each drug. Shared care agreements are still under development for some amber drugs. Until these are available, it would be expected that any shared care request from secondary care to a GP would be accompanied by written information which defines prescribing and monitoring responsibilities. The hospital specialist should also provide the GP with enough information and support to allow the safe transfer and ongoing management of prescribing into primary care.   

Green +

Drugs which should usually be initiated in secondary care, or by a specialist clinician, but can be safely maintained in primary care with very little or no monitoring required. In some cases there may be a further restriction for use outlined - these will be defined in each case.  

Green

These are defined as new and established drugs, which may be prescribed, initiated, changed or maintained on FP10 by the GP and, if appropriate, discontinued without recourse to secondary care. N.B. DRUGS NOT IDENTIFIED IN THE FORMULARY BY A RED, AMBER OR GREEN+ SYMBOL ARE CLASSIFIED AS GREEN.   

netFormulary