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Sunderland Joint Formulary
NHS Sunderland Clinical Commissioning Group
South Tyneside and Sunderland NHS Foundation Trust
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 Formulary Chapter 11: Eye - Full Chapter
11.01  Expand sub section  Administration of drugs to the eye
11.02  Expand sub section  Control of microbial contamination
11.03  Expand sub section  Anti-infective eye preparations
11.03.01  Expand sub section  Antibacterials
Fusidic Acid (Fucithalmic®)
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Formulary

Eye drops in gel basis (liquifies on contact with eye: 1%)

 
   
Azithromycin (Azyter®)
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Formulary

Eye drops: 1.5% (single use)

 
   
Chloramphenicol
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Formulary

Eye drops: 0.5%
Eye ointment: 1%
Minims® single use, preservative free: 0.5%

 
   
Ciprofloxacin
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Formulary

Eye drops: 0.3%
Eye ointment (preservative-free): 0.3%

 
   
Gentamicin (Genticin®)
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Eye drops: 0.3%

 
   
Levofloxacin
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Formulary

Eye drops: 0.5%
Unit dose eye drops: 0.5%

 
   
Moxifloxacin
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Formulary

Eye drops: 0.5%

 
   
Benzylpenicillin
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Formulary
Red

unlicensed Eye drops: 100,000 units/mL

 
   
Disodium Edetate
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Formulary
Red

unlicensed Eye drops: 0.37%

 
   
Ethanol
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Formulary
Red

unlicensed P/F Eye Drops: 18%

 
   
Gentamicin
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Formulary
Red

unlicensed unlicensed Eye drops: 1.5%
unlicensed unlicensed Eye drops (preservative free)1.5%

 
   
Hexamidine
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Formulary
Red

unlicensed unlicensed Eye drops: 0.1%

 
   
Polihexanide
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Formulary
Red

unlicensed unlicensed P/F eye drops: 0.02%
unlicensed unlicensed Eye drops: 0.06%

 
   
Potassium ascorbate
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Formulary
Red

unlicensed unlicensed Eye drops: 10%
unlicensed unlicensed P/F eye drops: 10%

 
   
Vancomycin
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Formulary
Red

unlicensed unlicensed Eye drops: 1.4%

 
   
11.03.02  Expand sub section  Antifungals to top
Chlorhexidine
Formulary
Red

unlicensed unlicensed Eye drops: 0.02%

 
   
Natamycin
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Formulary
Red

unlicensed unlicensed Eye drops: 5%

 
   
Voriconazole
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Formulary
Red

unlicensed unlicensed Eye drops: 1%

 
   
Amphotericin
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Formulary
Red

unlicensed unlicensed Eye drops: 0.15%

 
   
11.03.03  Expand sub section  Antivirals
Aciclovir
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Formulary

Eye ointment: 3%

 
   
Ganciclovir
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Formulary
Green +

Eye gel: 0.15%

 
   
Trifluorothymidine
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Formulary
Red

unlicensed unlicensed Preservative free eye drops: 1%

 
   
11.04  Expand sub section  Corticosteroids and other anti-inflammatory preparations
11.04.01  Expand sub section  Corticosteroids
Betamethasone
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Formulary

Eye/Ear/Nose drops: 0.1%
Eye ointment: 0.1%

 
   
Dexamethasone
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Formulary

Eye drops: 0.1%
Minims® (preservative free): 0.1%

 
   
Fluorometholone (FML®)
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Formulary
Green +

Eye drops: 0.1% with polyvinyl alcohol 1.4%

 
   
Loteprednol (Lotemax®)
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Formulary
Green +

Eye drops: 0.5%

 
   
Prednisolone
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Formulary
Green +

Eye drops: 0.5%
Minims® (preservative free): 0.5%
unlicensed unlicensed Eye drops: 0.003%, 0.01%, 0.03%, 0.1% and 0.3%
unlicensed unlicensed Eye drops (preservative free): 0.01%, 0.03%, 0.1%, 0.3%, 0.5% and 1%

 
   
Prednisolone
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Formulary
Green +

Eye drops: 1% (Pred Forte)

 
   
Betamethasone with Neomycin
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Formulary

Eye drops: betamethasone 0.1%, neomycin sulfate 0.5%

 
   
Dexamethasone with Neomycin and Polymyxin B sulphate (Maxitrol®)
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Formulary

Eye drops: 0.1%
Eye ointment: 0.1%

 
   
Dexamethasone with framycetin and gramicidin (Sofradex®)
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Formulary

Eye/Ear drops

 
   
Dexamethasone intravitreal implant
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Formulary
Red
High Cost Medicine

Intravitreal implant: 700 micrograms

 
Link  NICE TA229: Dexamethasone intravitreal implant for the treatment of macular oedema
Link  NICE TA349: Dexamethasone intravitreal implant for treating diabetic macular oedema
   
Fluocinolone intravitreal implant
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Red
High Cost Medicine

Intravitreal implant: 190 micrograms

 
Link  NICE TA 590: Fluocinolone acetonide intravitreal implant for treating recurrent non-infectious uveitis
Link  NICE TA301: Fluocinolone acetonide intravitreal implant for treating chronic diabetic macular oedema after an inadequate response to prior therapy (rapid review of technology appraisal guidance 271)
   
11.04.01  Expand sub section  Intravitreal corticosteroids
11.04.02  Expand sub section  Other anti-inflammatory preparations to top
Ketotifen  (Ketofall®)
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Formulary

Unit dose eye drops: 0.25 mg/mL, 0.4 mL

 
   
Lodoxamide
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Formulary

Eye drops: 0.1%

 
   
Neodocromil
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Formulary

Eye drops: 2%

 
   
Olopatadine
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Formulary

Eye drops: 1 mg/1 mL

 
   
Sodium Cromoglicate
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Formulary

Eye drops: 2%

 
   
Sodium Cromoglicate
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Formulary
Green +

unlicensed unlicensed Eye drops (preservative free): 2%

 
   
Ciclosporin
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Formulary
Green +

Eye drops: 0.1%

 
   
Ciclosporin
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Formulary
Red

unlicensed unlicensed P/F unit dose eye drops: 0.05%

 
   
11.05  Expand sub section  Mydriatics and cycloplegics
11.05  Expand sub section  Antimuscarinics
Atropine
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Formulary

Eye drops: 0.5%
Minims® (preservative free): 1%
unlicensed unlicensed Eye drops (preservative free): 1%
unlicensed unlicensed Eye ointment: 1%

 
   
Cyclopentolate
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Formulary

Eye drops: 0.5%, 1%
Minims® (preservative free): 0.5%, 1%

 
   
Cyclopentolate with phenylephrine
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Formulary
Red

unlicensed unlicensed Eye drops (preservative free): 1%

 
   
Tropicamide
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Formulary

Eye drops: 0.5%, 1%
Minims® (preservative free): 0.5%, 1%

 
   
11.05  Expand sub section  Sympathomimetics
Phenylephrine Hydrochloride
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Formulary

Minims® (preservative free): 2.5%, 10%
unlicensed unlicensed Eye drops: 2.5%

 
   
11.06  Expand sub section  Treatment of glaucoma
11.06  Expand sub section  Beta-blockers to top
Timolol
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Formulary

Eye drops: 0.25%, 0.5%
Unit dose eye drops (preservative-free): 0.25%, 0.5%
Eye drops gel forming solution (once daily): 0.25%, 0.5%
Eye drops (unit dose) (once daily, preservative-free): 0.1%
Preservative free eye drops (Eysano PF): 0.25%, 0.5%

 
   
Levobunolol
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Formulary

Eye drops: 0.5%
Unit dose eye drops: 0.5%

 
   
11.06  Expand sub section  Prostaglandin analogues
Bimatoprost
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Formulary

Eye drops: 100 micrograms/1 mL, 300 micrograms/1 mL
Unit dose eye drops (preservative-free): 300 micrograms/1 mL

 
   
Bimatoprost with Timolol
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Formulary

Eye drops: bimatoprost 300 micrograms/1 mL, timolol 5 mg/1 mL (Ganfort®)

 
   
Latanoprost
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Formulary

Eye drops: 50 micrograms/1 mL
Unit dose eye drops (preservative-free): 50 micrograms/1 mL

 
   
Latanoprost with Timolol
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Eye drops: latanoprost 50 micrograms/1 mL, timolol 5 mg/1 mL (Xalacom®)

 
   
Travoprost
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Formulary

Eye drops: 40 micrograms/1 mL

 
   
Travoprost with Timolol
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Formulary

Eye drops: travoprost 40 micrograms/1 mL, timolol 5 mg/1 mL (DuoTrav®)

 
   
11.06  Expand sub section  Sympathomimetics
Apraclonidine hydrochloride
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Formulary
Red

Eye drops: 0.5% Single use (preservative free): 1%

 
   
Brimonidine Tartrate
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Formulary

Eye drops: 0.2%

 
   
Brimonidine Tartrate with timolol
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Formulary

Eye drops: brimonidine 0.2%, timolol 0.5% (Combigan®)

 
   
11.06  Expand sub section  Carbonic anhydrase inhibitors and systemic drugs
Acetazolamide
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Formulary

Tablets: 250 mg
MR Capsules: 250 mg

 
   
Acetazolamide
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Formulary
Red

Injection: 500 mg vial

 
   
Brinzolamide
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Formulary

Eye drops: 1% (10 mg/1 mL)

 
   
Brinzolamide with timolol
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Formulary

Eye drops: brinzolamide 10 mg/1 mL, timolol 5 mg/1 mL (Azarga®)

 
   
Dorzolomide
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Formulary

Eye drops: 2%
Eye drops PF: 2% (Brands include Eydelto PF)
P/F unit dose eye drops: 2%

 
   
Dorzolomide with Timolol
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Formulary

Eye drops: dorzolamide 2%, timolol 0.5% (Cosopt®) (Eylamdo PF)
Single use (preservative free): dorzolamide 2%, timolol 0.5% (Cosopt®)

 
   
Brinzolamide and brimonidine (Simbrinza®)
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Formulary

Eye drops: brinzolamide 10mg/ml, brimonidine tartrate 2 mg/mL

 
   
11.06  Expand sub section  Miotics
Pilocarpine
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Formulary

Eye drops: 1%, 2%, 4%
Minims® (preservative free): 2%

 
   
11.07  Expand sub section  Local anaesthetics to top
Oxybuprocaine Hydrochloride
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Formulary
Red

Minims® eye drops (preservative free): 0.4%

 
   
Proxymetacaine Hydrochloride (Minims®)
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Formulary
Red

Minims® eye drops (preservative free): 0.5%

 
   
Tetracaine Hydrochloride
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Formulary
Red

Minims® eye drops (preservative free): 0.5%, 1%

 
   
Lidocaine with Fluorescein
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Formulary

P/F unit dose eye drop: 4%/0.25%

 
   
11.08  Expand sub section  Miscellaneous ophthalmic preparations
11.08.01  Expand sub section  Tear deficiency, ocular lubricants, and astringents
Acetylcysteine
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Formulary
Green +

Eye drops: acetylcysteine 5%, hypromellose 0.35% (Ilube®)
unlicensed unlicensed Eye drops (preservative-free): 5%,

 
   
Carbomer 980
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Formulary

Eye drops (liquid gel): 0.2%
Also available as single dose units (preservative-free)

 
   
Carmellose
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Formulary

Eye drops: 0.5%,
Single dose units (preservative-free): 0.5%, 1% (Celluvisc®)

 
   
Hylo Night Ointment
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Formulary

Eye ointment (containing retinol palmitate (vitamin A) 250iu/g, white soft paraffin, light liquid paraffin, liquid paraffin and wool fat)

 

N.B. This product was previously branded 'VitA-POS'

 
   
Hypromellose
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Formulary

Eye drops: 0.3%, 0.5%, 1%
Eye drops (preservative-free): 0.3%
unlicensed unlicensed Eye drops (preservative-free): 0.5%, 1%, 2%

 
   
Liquid Paraffin
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Formulary

Eye ointment:  white soft paraffin 57.3%, liquid paraffin 42.5%, wool alcohols 0.2%. (Lacri-Lube®)

 
   
Paraffin Yellow Soft
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Formulary

Ointment: liquid paraffin 10%, wool fat 10% in yellow soft paraffin (Simple Eye Ointment)

 
   
Povidone
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Formulary

unlicensed unlicensed Single dose units (preservative-free): 5%

 
   
Sodium Hyaluronate
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Formulary

Eye drops (preservative-free): 0.1% (Hylo-Tear®)
Eye drops (preservative-free): 0.2% (Hylo-Forte®)


Brands in primary care may vary

 
   
Systane (Contains hydroxypropyl guar, polyethylene glycol 400, propylene glycol (and other ingredients)
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Formulary

Eye drops: 10ml Multidose bottles
Eye drops: 0.8ml Preservative free vials

 
   
Polyvinyl Alcohol
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Formulary

Eye drops: 1.4% (Liquifilm Tears® and Sno Tears®)

 
   
11.08.02  Expand sub section  Ocular diagnostic and peri-operative preparations and photodynamic treatment
11.08.02  Expand sub section  Ocular diagnostic preparations
Fluorescein Sodium
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Formulary
Red

Minims® (preservative free): 1%, 2%

 
   
11.08.02  Expand sub section  Ocular peri-operative drugs to top
Apraclonidine
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Formulary
Red

Eye drops: 0.5%
Unit dose eye drops: 1%

 
   
Diclofenac
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Formulary
Red

Eye drops: 0.1%
Unit dose eye drops (preservative-free): 0.1%

 
   
Ketorolac
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Formulary
Red

Eye drops: 0.5%

 
   
Nepafenac
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Formulary
Red

Eye drops: 1 mg/1 mL

 
   
11.08.02  Expand sub section  Subfoveal choroidal neovascularisation
 note 

*Avastin is available as a treatment option for wet AMD in situations where ophthalmologists feel, in discussion with their patients, that the licensed options are unsuitable. See chapter 8 for product details.

Aflibercept
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Formulary
Red
High Cost Medicine

Intravitreal injection: 4 mg/ 0.1mL (dose 2mg/0.05ml)

 
Link  NICE TA 409: Aflibercept for treating visual impairment caused by macular oedema after branch retinal vein occlusion
Link  NICE TA 486: Aflibercept for treating choroidal neovascularisation
Link  NICE TA294: Macular degeneration (wet age-related) - aflibercept
Link  NICE TA305: Aflibercept for treating visual impairment caused by macular oedema secondary to central retinal vein occlusion
Link  NICE TA346: Aflibercept for treating diabetic macular oedema
   
Brolucuzumab
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Formulary
Red
High Cost Medicine

Intravitreal injection: 120mg/1mL (dose 6mg/0.05ml)

 
Link  NICE TA 672: Brolucizumab for treating wet age-related macular degeneration
   
Ranibizumab
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Formulary
Red
High Cost Medicine

Intravitreal injection: 10mg in 1ml as a 0.23ml vial (dose 0.5mg/0.05ml)

 
Link  NICE TA274: Macular oedema (diabetic) - ranibizumab
Link  NICE TA283: Macular oedema (retinal vein occlusion) - ranibizumab: guidance
Link  NICE TA298: Choroidal neovascularisation (pathological myopia) - ranibizumab
   
Verteporfin
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Formulary
Red
High Cost Medicine

Injection: 15 mg

 
   
11.08.02  Expand sub section  Vitreomacular traction
Ocriplasmin
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Formulary
Red
High Cost Medicine

Concentration for solution for intravitreal injection: 2.5mg/ml

 
Link  NICE TA297: Ocriplasmin for treating vitreomacular traction
   
11.09  Expand sub section  Contact lenses
11.99.99.99  Expand sub section  Miscellaneous
Cocaine
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Formulary
Red

unlicensed unlicensed P/F eye drops: 4%

 
   
11.99.99.99  Expand sub section  Antifungals to top
11.99.99.99  Expand sub section  Cytotoxics / wound healing modulators
11.99.99.99  Expand sub section  Fibrinolytic drugs
11.99.99.99  Expand sub section  Glues - ocular
11.99.99.99  Expand sub section  Immunosuppressants
11.99.99.99  Expand sub section  Treatment of burns to top
Sodium chloride
Formulary
Red

Unit dose eye drops: 0.9%
Eye drops: 5%
Eye ointment: 5%
P/F eye drops: 5%

 
   
11.99.99.99  Expand sub section  Visco-elastics
Sodium Hyaluronate
Formulary
Red

Prefilled syringe (Microvisc): 14mg/ml
Prefilled siringe (Provisc): 10mg/ml
Healon GV: 14mg/ml

 
   
11.99.99.99  Expand sub section  Other
Sodium Citrate
Formulary
Red

P/F eye drops: 10.11%

 
   
 ....
 Non Formulary Items
Acetazolamide oral liquid

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Non Formulary
 
Acetylcholine Chloride  (Miochol-E®)

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Non Formulary
 
Acetylcysteine

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Non Formulary
 
Alteplase intravitreal injection

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Non Formulary
 
Amo Complete

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Non Formulary
 
Antazoline 0.5% with Xylometazoline 0.05%  (Otrivine-Antistin®)

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Non Formulary
 
Azelastine  (Optilast®)

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Non Formulary
 
Betaxolol  (Betoptic®)

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Non Formulary
 
Boston Advance Cleaner

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Non Formulary
 
Boston Advance Conditioning Solution

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Non Formulary
 
Brilliant Peel®

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Non Formulary
 
Bromfenac  (Yellox®)

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Non Formulary
 
Carteolol  (Teoptic®)

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Non Formulary
 
Ceftazidime

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Non Formulary
 
Cefuroxime

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Non Formulary
 
Chlortetracycline

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Non Formulary
 
Dipivefrine Hydrochloride  (Propine®)

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Non Formulary
 
Econazole 1% eye drops

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Non Formulary
 
Epinastine  (Relestat®)

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Non Formulary
 
Cytotoxic Drug  Fluorouracil

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Non Formulary
 
Flurbiprofen Sodium  (Ocufen®)

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Non Formulary
 
Foscarnet intravitreal injection

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Non Formulary
 
Ganciclovir intravitreal injection

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Non Formulary
 
Glycerol (glycerin)

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Non Formulary
 
Homatropine

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Non Formulary
 
Hydrocortisone Acetate with Neomycin  (Neo-Cortef®)

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Non Formulary
 
Hydrocortisone eye ointment

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Non Formulary
 
Hydroxyethylcellulose  (Minims® Artificial Tears)

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Non Formulary
 
Idebenone  (Raxone®)

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Non Formulary
 
Indocyanine green

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Non Formulary
 
Ketotifen  (Zaditen®)

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Non Formulary
 
Metipranolol  (Minims® Metipranolol)

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Non Formulary
 
Miconazole 1% eye drops

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Non Formulary
 
Cytotoxic Drug  Mitomycin

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Non Formulary
 
Neomycin Eye drops

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Non Formulary
 
Oxysept 1 Step

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Non Formulary
 
Pegaptanib Sodium  (Macugen®)

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Non Formulary
High Cost Medicine
Link  NICE TA155: guidance on pegaptanib in AMD (August 2008)
 
Penicillin G

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Non Formulary
 
Polymyxin B Sulphate eye ointment  (Polyfax®)

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Non Formulary
 
Propamidine Isetionate  (Brolene®)

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Non Formulary
 
Rimexolone  (Vexol®)

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Non Formulary
 
Rose Bengal  (Minims® Rose Bengal)

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Non Formulary
 
Saline Solution

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Non Formulary
 
Soybean oil unit dose eye drops  (Emustil®)

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Non Formulary
 
Tafluprost and Timolol  (Taptiqom®)

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Non Formulary
 
Tissue Adhesive  (Histacryl®)

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Non Formulary
 
Total Care Daily Cleaner

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Non Formulary
 
Total Care Disinfecting and Wetting Solution

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Non Formulary
 
Viscoat Viscoelastic

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Non Formulary
 
  
Key
note Notes
Section Title Section Title (top level)
Section Title Section Title (sub level)
First Choice Item First Choice item
Non Formulary Item Non Formulary section
Restricted Drug
Restricted Drug
Unlicensed Drug
Unlicensed
Track Changes
Display tracking information
click to search medicines.org.uk
Link to adult BNF
click to search medicines.org.uk
Link to SPCs
Cytotoxic Drug
Cytotoxic Drug
CD
Controlled Drug
High Cost Medicine
High Cost Medicine
Cancer Drugs Fund
Cancer Drugs Fund
NHSE
NHS England
Homecare
Homecare
CCG
CCG

Traffic Light Status Information

Status Description

Red

Drugs for hospital use or use by a specialist within specialist centre only. Initiation and monitoring of treatment should remain under the total responsibility of the appropriate hospital clinician or specialist. These drugs should only be prescribed under the direct supervision of that clinician or specialist and are not suitable for shared care arrangements. The drug should be supplied via the hospital or specialist centre for the duration of treatment.   

Amber

These are specialist drugs which must be initiated by secondary care specialist prescribers, but with the potential to transfer prescribing to primary care within written and agreed shared care protocols and according to the agreed process for transfer of care. For these drugs, in order to ensure patient safety, some aspects of care must remain with the specialist due to their complexity e.g. monitoring of disease or drug response. Other more routine aspects can be transferred to the GP e.g. monitoring of adverse effects and supply of the medicine. The specific responsibilities of the specialist and GP are defined in the shared care agreement for each drug. Shared care agreements are still under development for some amber drugs. Until these are available, it would be expected that any shared care request from secondary care to a GP would be accompanied by written information which defines prescribing and monitoring responsibilities. The hospital specialist should also provide the GP with enough information and support to allow the safe transfer and ongoing management of prescribing into primary care.   

Green +

Drugs which should usually be initiated in secondary care, or by a specialist clinician, but can be safely maintained in primary care with very little or no monitoring required. In some cases there may be a further restriction for use outlined - these will be defined in each case.  

Green

These are defined as new and established drugs, which may be prescribed, initiated, changed or maintained on FP10 by the GP and, if appropriate, discontinued without recourse to secondary care. N.B. DRUGS NOT IDENTIFIED IN THE FORMULARY BY A RED, AMBER OR GREEN+ SYMBOL ARE CLASSIFIED AS GREEN.   

netFormulary