Sunderland Joint Formulary
NHS Sunderland Clinical Commissioning Group
South Tyneside and Sunderland NHS Foundation Trust

 
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9 Nutrition and blood
09-01-04 Drugs used in autoimmune thrombocytopenic purpura

Rituximab
Formulary

(1st line for ITP -Intravenous with oral Prednisolone or Dexamethasone)
Injection: 100mg, 500mg


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Anagrelide Xagrid®
Formulary

2nd line for ITP and patients at risk of essential thrombocythaemia
Capsules: 500micrograms


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Avatrombopag
Formulary
Link  NICE TA 626: Avatrombopag for treating thrombocytopenia in people with chronic liver disease needing a planned invasive procedure
 

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Caplacizumab Cablivi®
Formulary

Vial: powder and solvent for injection 10 mg

Link  NICE TA 667: Caplacizumab with plasma exchange and immunosuppression for treating acute acquired thrombotic thrombocytopenic purpura
 

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Eltrombopag Revolade®
Formulary

1st line for ITP patients who require treatment for bleeding, profound thrombocytopenia or to cover surgery during the Covid-19 pandemic
3rd line for severe, refractory ITP – choice according to patient preference

Tablets: 25mg, 50mg, 75mg

Link  Interim Clinical Commissioning Policy: Thrombopoietin receptor agonists as first line therapy for new or relapsed immune thrombocytopenia in adults and children over the age of 1 year during the COVID-19 pandemic
Link  NICE TA 293: Eltrombopag for treating chronic immune (idiopathic) thrombocytopenic purpura (review of technology appraisal 205)
 

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Lusutrombopag
Formulary

3mg film-coated tablets

Approved for use according to criteria in NICE TA617

Link  NICE TA 617: Lusutrombopag for treating thrombocytopenia in people with chronic liver disease needing a planned invasive procedure
 

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Romiplostim Nplate®
Formulary

1st line for ITP patients who require treatment for bleeding, profound thrombocytopenia or to cover surgery during the Covid-19 pandemic
3rd line for severe, refractory ITP – choice according to patient preference

Injection: 250 micrograms

Link  Interim Clinical Commissioning Policy: Thrombopoietin receptor agonists as first line therapy for new or relapsed immune thrombocytopenia in adults and children over the age of 1 year during the COVID-19 pandemic
Link  NICE TA 221: Thrombocytopenic purpura - romiplostim
 

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