North East and North Cumbria
ICS Formulary
 
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9 Nutrition and blood
09-01-03 Drugs used in hypoplastic, haemolytic, and renal anaemias

Eculizumab
Formulary
  • 300mg/30ml solution for infusion
  • Approved treating atypical haemolytic uraemic syndrome in adults and children in line with NICE

Paroxysmal nocturnal haemoglobinuria treatment is only commissioned from:

  • King’s College Hospital NHS Foundation Trust, London - London and South East
  • Leeds Teaching Hospitals NHS Trust - Rest of United Kingdom
Link   NICE TA647: Eculizumab for treating relapsing neuromyelitis optica (terminated appraisal)
Link  Clinical Commissioning Policy: Eculizumab in the treatment of recurrence of C3 glomerulopathy postkidney transplant (all ages) Reference: NHS England: 16054/P
Link  NICE HST 1 - Eculizumab for treating atypical haemolytic uraemic syndrome
Link  NICE TA636: Eculizumab for treating refractory myasthenia gravis (terminated appraisal)

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Pegcetacoplan Aspaveli®
Formulary
  • 1080mg/20 solution for infusion
  • Approved for the treatment paroxysmal nocturnal haemoglobinuria in adults who have anaemia after at least 3 months of treatment with a C5 inhibitor in line with NICE and NHSE Commissioning Policy.
  • Paroxysmal nocturnal haemoglobinuria treatment is only commissioned from:
    • King’s College Hospital NHS Foundation Trust, London - London and South East
    • Leeds Teaching Hospitals NHS Trust - Rest of United Kingdom

 

Link  NICE TA778: Pegcetacoplan for treating paroxysmal nocturnal haemoglobinuria

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Ravulizumab Ultomiris®
Formulary
  • 300mg/30ml & 1,100mg/11ml concentrate for solution for infusion
  • Approved for the treatment of paroxysmal nocturnal haemoglobinuria in adults in line with NICE
  • Approved for the treatment of atypical haemolytic uraemic syndrome in line with NICE
  • Paroxysmal nocturnal haemoglobinuria treatment is only commissioned from 
    • King’s College Hospital NHS Foundation Trust, London - London and South East
    • Leeds Teaching Hospitals NHS Trust - Rest of United Kingdom
Link  NICE TA698: Ravulizumab for treating paroxysmal nocturnal haemoglobinuria
Link  NICE TA710: Ravulizumab for treating atypical haemolytic uraemic syndrome

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Roxadustat Evrenzo®
Formulary
  • 20mg, 50mg, 70mg, 100mg and 150mg tablets
  • Approved for treating symptomatic anaemia associated with chronic kidney disease in adults in line with NICE
Link  NICE TA807: Roxadustat for treating symptomatic anaemia in chronic kidney disease

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