North East and North Cumbria
ICS Formulary
 
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4 Central nervous system
04-03-03 Selective serotonin re-uptake inhibitors

Citalopram
First Choice
  • Please note maximum doses
    • Adults = 40mg
    • Elderly = 20mg
Link  MHRA Drug Safety Update (Dec 2014): Citalopram and escitalopram: QT interval prolongation
Link  MHRA Drug Safety Update (Jan 2021): SSRI/SNRI antidepressant medicines: small increased risk of postpartum haemorrhage when used in the month before delivery
Link  MHRA Drug Safety Update (July 2016): Citalopram: suspected drug interaction with cocaine; prescribers should consider enquiring about illicit drug use

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Fluoxetine
First Choice
  • 20mg capsules
  • 20mg dispersible tablets
    • first choice for patients unable to use the capsules
  • 20mg/5ml oral solution
Link  MHRA Drug Safety Update (Jan 2021): SSRI/SNRI antidepressant medicines: small increased risk of postpartum haemorrhage when used in the month before delivery

Green View adult BNF  View SPC online  View childrens BNF
Paroxetine
First Choice
Link  MHRA Drug Safety Update (Jan 2021): SSRI/SNRI antidepressant medicines: small increased risk of postpartum haemorrhage when used in the month before delivery

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Sertraline
First Choice
  • 25mg, 50mg, 100mg, 150mg & 200mg tablets
  • 100mg/5ml concentrate for oral solution (Thame)
    • Approved for patients who are unable to take a solid dose form or who require small doses 
    • Must be diluted prior to use. Please refer to SPC for list of specified drinks
Link  MHRA Drug Safety Update (Jan 2021): SSRI/SNRI antidepressant medicines: small increased risk of postpartum haemorrhage when used in the month before delivery

Green View adult BNF  View SPC online  View childrens BNF
Escitalopram
Formulary
Link  MHRA Drug Safety Update (Dec 2014): Citalopram and escitalopram: QT interval prolongation
Link  MHRA Drug Safety Update (Jan 2021): SSRI/SNRI antidepressant medicines: small increased risk of postpartum haemorrhage when used in the month before delivery

Green View adult BNF  View SPC online  View childrens BNF