North East and North Cumbria
ICS Formulary
 
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3 Respiratory system

*Important*

The NENC ICB Respiratory Network recommends that all inhalers should be prescribed by brand for patient safety, to ensure that the correct device is dispensed to support correct technique and avoid patient confusion and medication errors.

Choice of inhaler device should be based on patient ability to use. Devices should be chosen based on availability for the type of drug to be prescribed and the patient’s ability to use it.

Refer to local guidelines for information on preferred options.

Note: All new patients should be started on the updated formulary choices as per local/national guidelines.

When inhalers are removed from the formulary, existing, stable, patients should continue to receive the non-formulary device. Treatment should not be changed unless a full face to face review has been conducted.

03-04-03 Angioedema

Berotralstat Orladeyo®
Formulary

  • 150mg capsule

  • Approved for preventing recurrent attacks of hereditary angioedema in people 12 years and older in line with NICE

Link  NICE TA738: Berotralstat for preventing recurrent attacks of hereditary angioedema

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C1 Esterase Inhibitor
Formulary

  • Approvded for the treatment and pre-procedure prevention of angioedema attacks in patients with hereditary angioedema (HAE).

  • Approvded for the routine prevention of angioedema attacks in adults and adolescents years old with severe and recurrent attacks of HAE.


 


 

Link  Clinical Commissioning Policy: Plasma-derived C1-esterase inhibitor for prophylactic treatment of hereditary angioedema (HAE) types I and II

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Conestat Alfa Ruconest®
Formulary
  • Vials: 2,100 units (as dry powder)

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Icatibant Firazyr®
Formulary

  • For use on the advice of immunologist in the treatment hereditary angioedema associated with C1-esterase inhibitor.


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Lanadelumab Takhzyro®
Formulary

  • 300mg/2mL solution for injection

    • Approved for preventing recurrent attacks of hereditary angioedema in line with NICE



Link  NICE TA606: Lanadelumab for preventing recurrent attacks of hereditary angioedema

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Danazol
Formulary
  • For use on the advice of an immunologist in the prophylaxis, treatment hereditary angioedema associated with C1-esterase inhibitor deficiency.
     

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Oxandrolone 2.5mg and 10mg capsules
Formulary
  • For use on the advice of an immunologist in the prophylaxis treatment hereditary angioedema associated with C1-esterase inhibitor deficiency when danzol and stanozolol are not available.

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Stanozolol 50mg tablets
Formulary
  • For use on the advice of an immunologist in the prophylaxis treatment hereditary angioedema associated with C1-esterase inhibitor deficiency.


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